Ana Mesic
PhD student Ecole Normale Supérieure Paris-Saclay| PhD
BIOMIS
4 avenue des sciences,
91190 Gif sur Yvette, France
room | 3X26, d’Alembert Institute
phone | + 33 (0)1 81 87 52 85
email | ana.mesic@ens-paris-saclay.fr
Phd subject description
DILI-on-chip (Drug Induced Liver Injury) project. Development of a microfluidic device to assess in vitro adverse drug reactions, on a human-like liver lobule. Combining microfluidics and novel biomaterials (hydrogels) with co-culture of four different cell types differentiated from iPSCs: hepatocytes, cholangiocytes, endothelial and Kupffer cells. Microfluidics will enable liver microarchitecture mimicking, compartmentalization and therefore creation of a 3D model. Additionally, q- valves will be introduced into the chip as a step toward the automatization and commercialization of the system.
Areas of expertise
organ on chip, microfluidics, tissue engineering
Biography
Education
2021- present | PhD, ENS Paris Saclay
2020- 2021 | MSc Microfluidics, Chimie ParisTech
2019- 2020 | MSc Biomedical Engineering, University Paris Descartes
2016- 2019 | BSc Molecular Biology, University of Zagreb
Professional experience
Drug Induced Liver Injury on a Chip, PhD
ENS Paris Saclay LuMIn, INSERM U1193, INSERM 1148, IES, Biopredic
2021- present
Skin on chip, 6-month internship
L’Oreal Research and Development, Laboratory of Cellular and Tissue Engineering
Feb 2021- July 2021
Droplet generator with integrated q- valves, 4- month internship
Institute Pierre Gilles de Gennes, Microfluidics, MEMS and Nanostructures Laboratory
Oct 2020- Jan 2021
Gene therapy for progressive deafness, 4-month internship
Pasteur Institute, Laboratory of Progressive Sensory Disorders, Pathophysiology and Therapy
Feb 2020- June 2020