{"id":32,"date":"2021-11-11T15:35:40","date_gmt":"2021-11-11T14:35:40","guid":{"rendered":"http:\/\/hebergement.universite-paris-saclay.fr\/biomis_d\/?page_id=32"},"modified":"2021-11-24T13:53:45","modified_gmt":"2021-11-24T12:53:45","slug":"alan-rajendran","status":"publish","type":"page","link":"https:\/\/hebergement.universite-paris-saclay.fr\/biomis_d\/?page_id=32","title":{"rendered":"Alan Rajendran"},"content":{"rendered":"\n
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Doctoral Student (2021-2024)<\/p>\n\n\n\n

Lumi\u00e8re, Mati\u00e8re et Interfaces (ENS Paris Saclay)<\/p>\n\n\n\n

Pathophysiology and therapeutics of liver diseases (Inserm U1193)<\/p>\n\n\n\n

EOBE Doctoral School,<\/p>\n\n\n\n

Universit\u00e9 Paris Saclay<\/p>\n\n\n\n

4 avenue des sciences<\/p>\n\n\n\n

91190 Gif-sur-Yvette, France <\/p>\n\n\n\n

Room | Piece 3X27, ENS Paris Saclay<\/p>\n\n\n\n

Phone | Tel +33 1 81 87 52 87<\/p>\n\n\n\n

Work : alan_raj_jeffrey.rajendran@ens-paris-saclay.fr<\/a><\/p>\n\n\n\n

Personal: alanrajjeffrey@gmail.com<\/a> <\/p>\n\n\n\n

Main research theme:<\/strong><\/p>\n\n\n\n

His doctoral study focuses on artificial tissue formation with the help of nanofabrication and soft-lithography. Since 2020, he has been working on creating parallel hepatic cords-on-chip.  This has been achieved by designing biomimetic micro-scaffolds capable of supporting long term cell culture. Artificial vasculature of fluid channels has been designed to provide the necessary metabolites, supply medium and extract tissue secretions. Continuous monitoring of tissue growth and the formation of hepatic polarity allows for the study of real time response of hepatic tissues to external stimuli and to study cell differentiation. <\/p>\n\n\n\n

During the course of the doctoral studies, formation of the Canal of Herring within chip is to be studied closely. Additionally, the use of biomaterials and iPSc derived hepatic cells will also be explored. <\/p>\n\n\n\n

Applications of his work targets drug toxicology studies during the preclinical stages and pharmacodynamics<\/p>\n\n\n\n

Academic and Professional Background:<\/strong><\/p>\n\n\n\n