Abstract : Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrincitrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including1H-1H and13C-27Al two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core–shell system. To do so,13C-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications.
Xue Li 1 Marianna Porcino 2 Jingwen Qiu 1 Doru Constantin 3 Charlotte Martineau-Corcos 4, 2, * Ruxandra Gref 1, *
* Auteur correspondant
1 ISMO – Institut des Sciences Moléculaires d’Orsay
2 CEMHTI – Conditions Extrêmes et Matériaux : Haute Température et Irradiation
3 LPS – Laboratoire de Physique des Solides
4 ILV – Institut Lavoisier de Versailles
